PROGNOSIS AND INTERFERENCE-MEDIATED TREATMENT OF BREAST CANCER

摘要

Six genes that are overexpressed in metastatic breast cancer, and in particular in bone and lung metastases of breast cancer are identified, and whose overexpression also correlates with underexpression of miR-335, miR-206 and/or miR-126 have been identified. Testing for levels of any one or more of the gene products or miRNA provides a prognostic/diagnostic indicator of the likelihood or presence of breast cancer metastases. In addition, agents that decrease the amount of protein gene product and/or increase the amount of one of the relevant miRNA can be used in the treatment of metastatic breast cancer.