HUMAN ANTI-FOLATE RECEPTOR ALPHA ANTIBODIES AND ANTIBODY FRAGMENTS FOR THE RADIOIMMUNOTHERAPY OF OVARIAN CARCINOMA

摘要

Antibody or fragment thereof, which specifically binds to folate receptor-alpha (FRa), wherein said antibody or fragment thereof comprises a light chain whose variable region comprises at least one of the following amino acid sequences : - RASESVSFLGINLIH (SEQ ID NO: 3), - QASNKDT (SEQ ID NO: 4), - LQSKNFPPYT (SEQ ID NO: 5), and wherein the constant region of said light chain is a kappa constant region.