| 摘要 |
The present invention relates to fatty acid analogues of the general formula (I): R<SUB>1</SUB>-[x<SUB>i</SUB>-CH<SUB>2</SUB>]<SUB>n</SUB>-COOR<SUB>2 </SUB>wherein R<SUB>1 </SUB>is; a C<SUB>1</SUB>-C<SUB>24 </SUB>alkene with one or more double bonds and/or with one or more triple bonds, and/or a C<SUB>1</SUB>-C<SUB>24 </SUB>alkyne, and/or a C<SUB>1</SUB>-C<SUB>24 </SUB>alkyl, or a C<SUB>1</SUB>-C<SUB>24 </SUB>alkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C<SUB>1</SUB>-C<SUB>4 </SUB>alkoxy, C<SUB>2</SUB>-C<SUB>4 </SUB>alkylthio, C<SUB>1</SUB>-C<SUB>5 </SUB>acyloxy or C<SUB>1</SUB>-C<SUB>4 </SUB>alkyl, and wherein R2 represents hydrogen or C<SUB>1</SUB>-C<SUB>4 </SUB>alkyl, and wherein n is an integer from 1 to 12, and wherein i is an odd number and indicates the position relative to COOR<SUB>2</SUB>, and wherein X<SUB>i </SUB>independent of each other are selected from the group comprising O, S, SO, SO<SUB>2</SUB>, Se and CH<SUB>2</SUB>, and with the proviso that at least one of the X<SUB>i </SUB>is not CH<SUB>2</SUB>, and with the proviso that if R1 is an alkyne or alkene, then the carbon-carbon triple bond or double bond is positioned between the (omega-1) carbon and the (omega-2) carbon, or between the (omega-2) carbon and the (omega-3) carbon, or between the (omega-3) carbon and the (omega-4) carbon, which can be used for the treatment and/or prevention of proliferative skin disorders. More specifically the invention relates to the inhibition of proliferation and/or differentiation of keratinocytes.
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