USE OF RUBESCENSINE A AND DERIVATIVES THEREOF IN PHARMACY

摘要

Use of Rubescensine A and derivatives thereof in pharmacy. Rubescensine A can induce the apoptosis of leukemia cells in vitro, and can prolong the survival period of mouse model of t(8;21) leukemia in vivo or delay the growth of tumor in body. Sequential, joint application of Rubescensine A and chemotherapeutics, such as cytarabine or agents for inducing differentiation may be more effective in prolonging the survival period of mouse of t(8;21) leukemia.