IMPROVED NEUROSPORA HOSTS FOR THE PRODUCTION OF RECOMBINANT PROTEINS, AND METHODS FOR PRODUCING THE SAME

摘要

The present invention provides improved host cells for use in producing secreted recombinant proteins, methods of making the improved hosts and uses thereof. The invention specifically provides strains of Neurospora crassa which produce reduced levels of extracellular proteases when compared with wild-type Neurospora crassa.