| 摘要 |
Provided is a compound comprising the structure: O- (x-L)n, wherein: O is an oligonucleotide comprising at least 10 bases exactly complementary to the human telomerase RNA sequence. x is an optional linker and, if present, is an aminoglycerol linker or a glycerol linker; L is a lipid moiety; and n is an integer from 1-5, wherein if n > 1, each (x-L) component is independently selected. Further provided are similar compounds with specified lipid components and methods of inhibiting telomerase activity in vitro and ex vivo. |
