Once-a-day oxycodone formulations

摘要

Disclosed is a sustained release osmotic oral dosage form comprising: (a) a bilayer core comprising: (i) a drug layer comprising from about 1 mg to about 640 mg oxycodone or a pharmaceutically acceptable salt thereof; and (ii) a displacement layer comprising an osmopolymer; and (b) a semipermeable wall surrounding the bilayer core having a passageway disposed therein for the release of said oxycodone or pharmaceutically acceptable salt thereof; said dosage form providing an analgesic effect for at least about 24 hours and a mean C24/Cmax oxycodone ratio of 0.6 to 1.0 after once-a-day oral administration at steady state to human patients.