| 发明名称 |
ANTAGONIST ANTI-NOTCH3 ANTIBODIES AND THEIR USE IN THE PREVENTION AND TREATMENT OF NOTCH3-RELATED DISEASES. |
| 摘要 |
<p>The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.</p> |
| 申请公布号 |
MX2009006500(A) |
申请公布日期 |
2009.06.26 |
| 申请号 |
MX20090006500 |
申请日期 |
2007.12.17 |
| 申请人 |
GENENTECH, INC. |
发明人 |
LI, KANG;FUNG, SEK CHUNG;ZHOU, BIN-BING STEPHEN;SINGH, SANJAYA;LI, YUCHENG |
| 分类号 |
C07K16/28;A61K39/395;A61P35/00;C12N5/12;C12N15/13 |
主分类号 |
C07K16/28 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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