发明名称 |
Compositions and Methods for Effecting NAD+ Levels Using A Nicotinamide Phosphoribosyl Tranferase Inhibitor |
摘要 |
The present invention relates to methods for decreasing cellular DNA repair in a target patient; decreasing cellular NAD+ biosynthesis in a target patient; increasing efficiency of radiation therapy in a target patient; modulating nicotinamide phosphoribosyl transferase activity in a patient; or sensitizing a patient to a DNA damaging therapy. The invention relates to methods for treating a patient who received a toxic dose of an nicotinamide phosphoribosyl transferase inhibitor. The invention also relates to pharmaceutical compositions comprising a physiologically acceptable carrier; an effective amount of a NMPRT inhibitor; and nicotinic acid. The invention also relates to methods for treating a patient diagnosed with or suspected to have a cancer deficient in nicotinic acid pathway.
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申请公布号 |
US2009162454(A1) |
申请公布日期 |
2009.06.25 |
申请号 |
US20080237755 |
申请日期 |
2008.09.25 |
申请人 |
ROULSTON ANNE;BEAUPARLANT PIERRE |
发明人 |
ROULSTON ANNE;BEAUPARLANT PIERRE |
分类号 |
A61K33/24;A61K31/282;A61K31/4406;A61K31/4545;A61K31/4985;A61K31/519;A61K31/66;A61K31/7052;A61K31/7076;A61K38/12;A61P35/00 |
主分类号 |
A61K33/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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