发明名称 |
CROSSLINKED HYALURONIC ACID IN EMULSION |
摘要 |
<p>The present invention relates to methods of producing crosslinked hyaluronic acid microbeads, as well as the produced microbeads, said method comprising the steps of: (a) mixing an aqueous alkaline solution comprising hyaluronic acid, or a salt thereof, with a solution comprising a crosslinking agent; (b) forming microdroplets having a desired size from the mixed solution of step (a) in an organic or oil phase to form a water in organic or water in oil (W/O) emulsion; (c) continuously stirring the W/O emulsion, whereby the reaction of hyaluronic acid with divinylsulfone takes place to provide crosslinked hyaluronic acid microbeads; and (d) purifying the crosslinked hyaluronic acid microbeads.</p> |
申请公布号 |
WO2009077620(A1) |
申请公布日期 |
2009.06.25 |
申请号 |
WO2008EP68050 |
申请日期 |
2008.12.19 |
申请人 |
NOVOZYMES BIOPOLYMER A/S;MALLE, BIRGITTE, MOELHOLM |
发明人 |
MALLE, BIRGITTE, MOELHOLM |
分类号 |
C08B37/00;C08L5/08 |
主分类号 |
C08B37/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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