发明名称 |
Mesothelin Vaccines and Model Systems |
摘要 |
Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic T cell response. Portions of mesothelin which induce such responses are identified. Vaccines can be either polynucleotide- or polypeptide-based. Carriers for raising a cytolytic T cell response include bacteria and viruses. A mouse model for testing vaccines and other anti-tumor therapeutics and prophylactics comprises a strongly mesothelin-expressing, transformed peritoneal cell line.
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申请公布号 |
US2009165152(A1) |
申请公布日期 |
2009.06.25 |
申请号 |
US20080210604 |
申请日期 |
2008.09.15 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
JAFFEE ELIZABETH;WU TZYY-CHOOU;HUNG CHIEN-FU;HRUBAN RALPH |
分类号 |
A61B10/00;A01K67/027;A61K39/00;C12N5/10;C12Q1/68 |
主分类号 |
A61B10/00 |
代理机构 |
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代理人 |
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地址 |
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