摘要 |
<p>The invention relates to the use of nanoparticles having dimensions between 1 and 50 nm, at least one part of which is constituted of at least one oxide and/or one oxyhydroxide of at least lanthanide, said nanoparticles being: - either constituted of at least one oxide and/or one oxyhydroxide of at least one lanthanide, - or in the form of nanoparticles comprising an oxyhydroxide core of at least one lanthanide, and a coating constituted of a polysiloxane, optionally with organic molecules grafted to the surface or included within it, as a radiosensitizing agent in the manufacture of an injectable composition intended for improving the effectiveness of the treatment of a tumour by X-ray or gamma irradiation. It also relates to nanoparticles that are particularly suitable for the above use, constituted of a core constituted of at least one oxide and/or one oxyhydroxide of at least one lanthanide and of a polysiloxane coating comprising 1 to 5 silicons per lanthanide and of which at least 10% of the silicon atoms are linked to hydrophilic organic molecules having molar masses of less than 450 g/mol.</p> |
申请人 |
UNIVERSITE CLAUDE BERNARD LYON I;HOSPICES CIVILS DE LYON;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;NANOH;EUROPEAN SYNCHROTRON RADIATION FACILITY (INSTALLATION EUROPEENNE DE RAYONNEMENT SYNCHROTRON);TILLEMENT, OLIVIER;ROUX, STEPHANE;PERRIAT, PASCAL;LEDUC, GERALDINE;MANDON, CELINE;MUTELET, BRICE;ALRIC, CHRISTOPHE;BILLOTEY, CLAIRE;JANIER, MARC;LOUIS, CEDRIC |
发明人 |
TILLEMENT, OLIVIER;ROUX, STEPHANE;PERRIAT, PASCAL;LEDUC, GERALDINE;MANDON, CELINE;MUTELET, BRICE;ALRIC, CHRISTOPHE;BILLOTEY, CLAIRE;JANIER, MARC;LOUIS, CEDRIC |