发明名称 |
SALICYLANILIDES ENHANCE ORAL DELIVERY OF THERAPEUTIC PEPTIDES |
摘要 |
This invention pertains to the surprising discovery that salicylanilides, e.g., niclosamide and/or niclosamide analogues when orally administered in conjunction with a peptide pharmaceutical (e.g., a class A amphipathic helical peptide as described herein) significantly increases the bioavailability of that peptide. Methods of peptide delivery using such "delivery agents" and pharmaceutical formulations are provided.
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申请公布号 |
US2009163408(A1) |
申请公布日期 |
2009.06.25 |
申请号 |
US20070835338 |
申请日期 |
2007.08.07 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
FOGELMAN ALAN M.;NAVAB MOHAMAD |
分类号 |
A61K38/16;A61K38/02;A61K38/03;A61K38/08;A61K38/10;A61K47/00 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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