发明名称 |
MODULATING IMMUNE SYSTEM DEVELOPMENT AND FUNCTION THROUGH MICRORNA MIR-146 |
摘要 |
<p>The present disclosure relates to the finding that microRNA-146 plays a role in modulating the development and function of the immune system. Immune cell development and function can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells or precursor cells. For example, in some embodiments, activity and/or proliferation of certain immune cells is regulated by administering miR-146 oligonucleotides or anti-miR-146 oligonucleotides. In other embodiments, pro-inflammatory cytokine expression in immune cells is regulated by administering a miR-146 oligonucleotide or anti-miR-146. In further embodiments, methods of regulating macrophage activity using antisense miR-146 are provided. Additional methods and compositions for regulating immune system function and development using miR-146 are disclosed.</p> |
申请公布号 |
WO2009079592(A2) |
申请公布日期 |
2009.06.25 |
申请号 |
WO2008US87249 |
申请日期 |
2008.12.17 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY;BALTIMORE, DAVID;BOLDIN, MARK;TAGANOV, KONSTANTIN |
发明人 |
BALTIMORE, DAVID;BOLDIN, MARK;TAGANOV, KONSTANTIN |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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地址 |
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