发明名称 |
Multicomponent coupling and glycopeptide synthesis with cyclic thioanhydrides |
摘要 |
Disclosed is a method of coupling an amino or hydroxyl compound with the amino portion of a sulfonamide via condensation with a cyclic thioanhydride. The reaction of cyclic thioanhydrides with amines affords amides functionalized with thioacids, which can be trapped in situ with preferably electron deficient arylsulfonamides. In this manner the cyclic thioanhydride serves as a linchpin in a three component coupling sequence.
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申请公布号 |
US2009163697(A1) |
申请公布日期 |
2009.06.25 |
申请号 |
US20080317139 |
申请日期 |
2008.12.19 |
申请人 |
CRICH DAVID;BOWERS ALBERT A |
发明人 |
CRICH DAVID;BOWERS ALBERT A. |
分类号 |
C07K1/107;C07C227/18;C07D279/16;C07D295/15;C07H1/00 |
主分类号 |
C07K1/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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