发明名称 |
METHOD FOR MANUFACTURE OF ESCITALOPRAM |
摘要 |
<p>the patent discloses a method for resolution of 4-[4-(dimethylamino)-1-(4'-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile as a racemic or non-racemic enantiomer mixture into its isolated enantiomers, said method comprising the step of fractionally crystallising 4-[4-(dimethylamino)-1-(4'-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile as a salt with the (+)-(S,S)- or (-)-(R,R)-enantiomer of O,O'-di-p-toluoyl-tartaric acid in a solvent system comprising 1-propanol, ethanol or acetonitrile.</p> |
申请公布号 |
LT5577(B) |
申请公布日期 |
2009.06.25 |
申请号 |
LT20080000068 |
申请日期 |
2008.09.03 |
申请人 |
H. LUNDBECK A/S |
发明人 |
FAVERI, CARLA, DE;HUBER, FLORIAN, ANTON MARTIN;DANCER, ROBERT, JAMES |
分类号 |
C07D307/00 |
主分类号 |
C07D307/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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