发明名称 |
MISUSE PREVENTATIVE, CONTROLLED RELEASE FORMULATION |
摘要 |
Disclosed is a misuse preventative, controlled release formulation comprising a core comprising a superabsorbent material (for example, polycarbophil), a controlled release coat surrounding the core, and a plurality of controlled release microparticles having a pharmaceutically active agent (for example, an opioid analgesic) disposed within the core, the coat, or both the core and the coat. When crushed, either intentionally or accidentally, and exposed to an aqueous medium, the superabsorbent material present in the core swells to encapsulate the microparticles, which remain substantially intact thereby retarding the release of the pharmaceutically active agent from the formulation. Also disclosed is a method of using the misuse preventative, controlled release formulation to deliver a pharmaceutically active agent to a mammal, for example, a human, in need thereof. |
申请公布号 |
CA2707980(A1) |
申请公布日期 |
2009.06.25 |
申请号 |
CA20082707980 |
申请日期 |
2008.12.16 |
申请人 |
LABOPHARM, INC.;LABOPHARM EUROPE LIMITED;LABOPHARM (BARBADOS) LIMITED |
发明人 |
RAHMOUNI, MILOUD;SANT, VINAYAK;GERVAIS, SONIA;SMITH, DAMON;DUFFAYET, FREDERIC;RUSTOMS, SHAMS;EL-JAMMAL, ALI;BOURSIQUOT, BOBBY-ERNST;BICHARA, ALI;NDONG, JEAN-MICHEL;FERRADA, ANGELA;SOULHI, FOUZIA |
分类号 |
A61K9/16;A61K9/14;A61K9/26;A61K9/52;A61K31/00;A61K47/30;A61K47/36;A61K47/38 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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