| 摘要 |
As described herein, leptin treatment significantly increased wound contraction and epithelial regeneration while reducing granulation tissue and wound area, consistent with a healing augmentation effect. Specifically, in leptin-treated wounds, the inventor found increased expression of smooth muscle -actin ( -SMA) and collagens I, III and IV. Taken together, the inventor's results indicate that a major functional theme for the accelerated wound healing action of leptin consists of the acute, local induction of genes whose expression are critical for repair and contraction. Thus, the invention relates to methods and compositions for the promotion and/or acceleration of wound repair, re-epithelialization, wound contraction and decrease of granulation tissue by administering leptin to the subject, as well as methods for studying this process.
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