<p>This invention provides a trimeric protein complex that presents an exposed N-terminal coiled-coil domain from the HIV gp41 protein. The preferred embodiment of the invention inhibits membrane fusion mediated by HIV virus. The invention also provides methods to use the trimeric protein complexes as a vaccines to prevent infection by the HIV virus.</p>
申请公布号
EP1463521(A4)
申请公布日期
2009.06.24
申请号
EP20020795951
申请日期
2002.12.17
申请人
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人
CLORE, G., MARIUS;BEWLEY-CLORE, CAROLE, A.;MEDABALIMI, JOHN, L.
