Method for reprogramming in vitro stem cells and somatic cells into germinal cells

摘要

The present invention is related to a method for inducing in vitro the differentiation of stem cells or somatic cells towards germinal cells, comprising the following steps :
€¢ cultivating said stem cells or somatic cells in a medium allowing their differentiation, and
€¢ collecting the germinal cells from the culture medium,
wherein said cells are cells transformed with an exogenous genetic construction comprising at least a Vasa gene.
Germinal cells such as obtained and chimeric animals are also an object of this invention.