发明名称 |
EXPRESSION VECTORS FOR ENHANCED TRANSIENT GENE EXPRESSION AND MAMMALIAN CELLS EXPRESSING THEM |
摘要 |
<p>This invention relates to the unexpected discovery that nucleotide coding sequences coding for a truncated Epstein Barr Nuclear Antigen 1 (EBNA1t) protein (lacking the Gly-Gly-Ala domain), when in cells of mammalian origin, are associated with improved growth and increased transient gene expression when compared with cells expressing a complete EBNA1 coding sequence. The expression of EBNA1t also appear to be more stable over time.</p> |
申请公布号 |
EP1861498(A4) |
申请公布日期 |
2009.06.24 |
申请号 |
EP20060721674 |
申请日期 |
2006.03.17 |
申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
DUROCHER, YVES |
分类号 |
C12N15/38;C07K14/05;C12N5/10;C12N15/86;C12P21/00 |
主分类号 |
C12N15/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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