发明名称 Controlled release polymer nanoparticle containing bound nucleic acid ligand for targeting
摘要 The present invention relates to a conjugate that includes a nucleic acid ligand bound to a controlled release polymer system, a pharmaceutical composition that contains the conjugate, and methods of treatment using the conjugate. The controlled release polymer system includes an agent such as a therapeutic, diagnostic, prognostic, or prophylactic agent. The nucleic acid ligand that is bound to the controlled release polymer system, binds selectively to a target, such as a cell surface antigen, and thereby delivers the controlled release polymer system to the target.
申请公布号 US7550441(B2) 申请公布日期 2009.06.23
申请号 US20040860918 申请日期 2004.06.04
申请人 MASSACHUSETTS INSTITUTE OF TECHNOLOGY 发明人 FAROKHZAD OMID C.;JON SANGYONG;LANGER ROBERT S.
分类号 A61K31/7088;A61K;A61K9/127;A61K9/14;A61K9/16;A61K9/22;A61K9/51;A61K31/713;A61K47/48;A61K48/00;C12N11/00;C12N15/87;C12Q1/00 主分类号 A61K31/7088
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