| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: in the new compounds with formula I Ar is a bivalent group, formed by removal of two hydrogen atoms from benzol, pyrimidine or pyridine (this bivalent group can also be substituted with a halogen atom, inferior alkoxy (this inferior alkoxy group can also be substituted with a halogen), hydroxyl or inferior alkyl); X1 is an oxygen atom; R1 is a straight or branched inferior alkyl (this inferior alkyl group can also be substituted with hydroxy, halogen, alkoxy, allyloxy or aralkyloxy ), phenyl, aralkyl or alkoxy; ring A is a 5- or 6- member heteroaryl ring, containing 1 or 2 nitrogen atoms or a sulphur atom in the ring, or a benzene ring; R2 and R3 can be identical or different from each other, and each represents hydrogen, amino, alkylamino, hydroxyl, inferior alkylsulphonyl, halogen, inferior alkyl (this inferior alkyl group can also be substituted with a halogen), inferior cycloalkyl (this inferior cycloalkyl group can also be substituted with a halogen), inferior alkoxy (this inferior alkoxy group can also be substituted with a halogen), aryl, heteroaryl, mono inferior alkylcarbamoyl, inferior alkylcarboxamide, arylcarboxamide, inferior alkylsulphonylamino, alkylaminosulphonyl, aralkyl or alkanoylakylamino or; Y is CH or a nitrogen atom; -X2 is a group with formula (II) (where R4 and R5 and a the nitrogen atom, taken together, can form a 5-8-member monocyclic ring (this monocyclic ring can be substituted with a halogen atom, oxo group or inferior alkyl group, which can be substituted by a halogen itself), or a 6-10-member bicyclo-ring, n is an integer, which assumes values 3 or 4, and (CH2)n can be substituted with an inferior alkyl group, containing 1-3 carbon atoms), with formula (III) (where m is and integer which assumes values from 0 to 4, and R6 is an inferior alkyl or cycloalkyl group) or formula (IV) , where symbols assume values given above. The invention also relates to agents for preventing or curing metabolic diseases, blood circulatory diseases or diseases of the nervous system, containing formula I compounds. ^ EFFECT: new compounds can be used in medicine. ^ 18 cl, 279 ex |
