| 摘要 |
FIELD: biotechnologies. ^ SUBSTANCE: invention refers to biotechnology, and namely to analysis method of heparins or low-molecular heparins, and can be used when controlling samples, and for standardising Lovenox method and obtaining homogeneous products. Method of quantitative determination of heparins or low-molecular heparins is implemented by means of the following stages: sample is depolymerised with heparinases, then the obtained depolymerisate is reduced, and after that the analysis is performed by means of high-efficiency liquid chromatography. ^ EFFECT: this invention allows to clearly differentiate Lovenox from other low-molecular heparins not containing "1,6-anhydro" derivatives. ^ 7 cl, 2 dwg, 1 tbl, 6 ex |
