| 摘要 |
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, particularly to neonatology. Method of late neonatal sepsis prediction in premature infants involves estimation of informative signs within the first 4-6 days of life. Diagnostic factors are specified for each sign with informativity decrease: observed recovery of complete parenteral nutrition allows for diagnostic factor 0.59. If complete parenteral nutrition is not recovered, diagnostic factor (-)0.54 is specified. Concentration of standard bicarbonates in capillary blood >21 mmol/l ensures diagnostic factor 0.37, while concentration of standard bicarbonates in capillary blood ëñ21 mmol/l shows diagnostic factor (-)0.59. Observed intraventricular hemorrhages of degree 3-4 show diagnostic factor being 0.54. In case intraventricular hemorrhages of degree 3-4 are not observed, diagnostic factor is (-)0.23; average indicator of oxygen saturation >70% provides diagnostic factor (-)0.19, while average indicator of oxygen saturation ëñ70% indicates diagnostic factor 0.63. Indicator of erythrocyte volume distribution >16% allows for diagnostic factor 0.36, and with this indicator ëñ16%, diagnostic factor is (-)0.31. Breast feeding ensures diagnostic factor (-)0.46, while artificial or mixed feeding provides diagnostic factor 0.18; in monocyte fraction >16%, diagnostic factor is 0.07, while in monocyte fraction ëñ16% diagnostic factor is (-)0.12. Then diagnostic factors (DF) are summed starting with correction (-)0.129, and the patient is considered to be referred to the group of potential development of late neonatal sepsis if total diagnostic factors in informativity decreasing order at certain analysis stage is equal or exceeds upper threshold 0.68. The patient is referred to the group of absent data specifying development of late neonatal sepsis if total diagnostic factors are equal or less than lower threshold (-)1.2. Method provides integrated estimate approach and multifactorality of late neonatal sepsis development at premature infants. ^ EFFECT: accurate prediction allows reducing probability of lethal outcomes due to early change of therapeutic tactics. ^ 1 tbl, 4 ex |
