| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: extraction is done using affinity chromatography with immobilised metal. The method can be realised in native conditions. Biologically active G-CSF is obtained with purity over 95%. Two more chromatography stages are done, cation-exchange and gel filtration, to remove trace amounts of impurities. The method allows for obtaining G-CSF with high output and over 99% purity. ^ EFFECT: described method is especially suitable for industrial production of G-CSF. ^ 16 cl, 5 dwg, 5 ex |
