| 发明名称 |
WNT ANTAGONISTS AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF WNT-MEDIATED DISORDERS. |
| 摘要 |
<p>The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.</p> |
| 申请公布号 |
MX2009002522(A) |
申请公布日期 |
2009.06.19 |
| 申请号 |
MX20090002522 |
申请日期 |
2007.09.07 |
| 申请人 |
GENENTECH, INC. |
发明人 |
POLAKIS, PAUL;ERNST, JAMES, A.;RUBINFELD, BONNEE;DE ALMEIDA, VENITA, I. |
| 分类号 |
A61K38/17;C07K14/705;C12N15/62;G01N33/50 |
主分类号 |
A61K38/17 |
| 代理机构 |
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