发明名称 |
HUMAN ENDOGENOUS RETROVIRUS POLYPEPTIDE COMPOSITIONS AND METHODS OF USE THEREOF |
摘要 |
<p>The present invention provides isolated HERV polypeptides; and compositions, including immunogenic compositions, comprising a HERV polypeptide. The present invention provides immunogenic compositions comprising a nucleic acid comprising a nucleotide sequence encoding a HERV polypeptide. The immunogenic compositions are useful for stimulating a T cell immune response to a lentiviral peptide. The present invention further provides methods of stimulating an immune response in an individual to a retrovirus-or lentivirus-infected cell. The present invention further provides methods of treating cancers in which HERV polypeptides are expressed. Also provided are methods of treating disorders, involving decreasing an immune response to a HERV polypeptide.</p> |
申请公布号 |
KR20090060410(A) |
申请公布日期 |
2009.06.12 |
申请号 |
KR20097003239 |
申请日期 |
2009.02.17 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;THE J. DAVID GLADSTONE INSTITUTES;ALBERT EINSTEIN COLLEGE OF MEDICINE;OSTROWSKI MARIO;JONES R. BRADLEY;RAKOFF NAHOUM SETH |
发明人 |
OSTROWSKI MARIO;JONES R. BRADLEY;RAKOFF NAHOUM SETH;NIXON DOUGLAS;GARRISON KEITH;MEIKLEJOHN DUNCAN;AGRAWAL ASHISH;LENZ JACK;HECHT FREDERICK M. |
分类号 |
A61K39/21;A61K38/08;A61K48/00;A61P37/04 |
主分类号 |
A61K39/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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