发明名称 AMINOTETRALIN COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS
摘要 The invention provides aminotetralin compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, n, and m are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
申请公布号 US2009149465(A1) 申请公布日期 2009.06.11
申请号 US20080331627 申请日期 2008.12.10
申请人 LEADBETTER MICHAEL R;TRAPP SEAN G;LONG DANIEL D;JACOBSEN JOHN R;AXT SABINE 发明人 LEADBETTER MICHAEL R.;TRAPP SEAN G.;LONG DANIEL D.;JACOBSEN JOHN R.;AXT SABINE
分类号 A61K31/495;A61K31/165;A61K31/445;A61P1/00;C07C237/20;C07D211/32;C07D241/04;C12Q1/02 主分类号 A61K31/495
代理机构 代理人
主权项
地址