发明名称 |
Oligonucleotide analogues and methods utilizing the same |
摘要 |
A method for the prevention or treatment in a mammal of a disease preventable or treatable by the pharmacologically useful antisense or antigene activity of an oligonucleotide analogue or a pharmacologically acceptable salt thereof in the body of said mammal, which method comprises administering to said mammal in need of such prevention or treatment a pharmaceutically effective amount of an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of said nucleoside units is a structure of the formula (2): wherein A is methylene; and B is an unsubstituted purin-9-yl, an unsubstituted 2-oxo-pyrimidin-1-yl or a substituted purin-9-yl; or a pharmacologically acceptable salt thereof.
|
申请公布号 |
US2009149404(A1) |
申请公布日期 |
2009.06.11 |
申请号 |
US20070881775 |
申请日期 |
2007.07.27 |
申请人 |
DAIICHI SANKYO COMPANY, LIMITED;MITSUBISHI-KAGAKU FOODS CORPORATION |
发明人 |
KANEKO MASAKATSU;MORITA KOJI;IMANISHI TAKESHI |
分类号 |
A61K31/7084;C12N15/09;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7068;A61K31/7076;A61K31/7088;A61K31/712;A61K48/00;A61P31/12;A61P35/00;A61P43/00;C07H19/06;C07H19/067;C07H19/10;C07H19/16;C07H19/167;C07H19/20;C07H21/00;C07H21/02;C12Q1/68 |
主分类号 |
A61K31/7084 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|