| 摘要 |
<p>Substituted 2-naphthoic acids of structural formula I are effective as antagonists of the biological activity of GPR105 protein. They are useful for the treatment, control or prevention of disorders responsive to antagonism of this receptor, such as diabetes, particularly, Type 2 diabetes, insulin resistance, hyperglycemia, lipid disorders, obesity, atherosclerosis, and conditions associated with the Metabolic Syndrome.</p> |
| 申请人 |
MERCK FROSST CANADA LTD.;BELLEY, MICHEL;DESCHENES, DENIS;FORTIN, REJEAN;FOURNIER, JEAN-FRANCOIS;GAGNE, SEBASTIEN;GAREAU, YVES;GAUTHIER, JACQUES, YVES;LI, LIANHAI;ROBICHAUD, JOEL;THERIEN, MICHEL;TRANMER, GEOFFREY, K.;WANG, ZHAOYIN |
发明人 |
BELLEY, MICHEL;DESCHENES, DENIS;FORTIN, REJEAN;FOURNIER, JEAN-FRANCOIS;GAGNE, SEBASTIEN;GAREAU, YVES;GAUTHIER, JACQUES, YVES;LI, LIANHAI;ROBICHAUD, JOEL;THERIEN, MICHEL;TRANMER, GEOFFREY, K.;WANG, ZHAOYIN |
