| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide an anti-oxidative stress agent that enhances ARE enhancer activity in an Nrf2-ARE pathway, induces expression of a group of antioxidative protein and ameliorates an oxidative stress. <P>SOLUTION: The sesquiterpene lactone derivative is represented by formula 1 etc. The compound improves fragility to oxidative stress and is effective for preventing and treating oxidative stress-associated neurodegenerative disease, ischemic cerebrovascular disorder, ischemic heart disease, inflammatory intestinal disease, eye disease, rheumatism etc. <P>COPYRIGHT: (C)2009,JPO&INPIT |
