PERFLUORO-ARYLIODONIUM SALTS IN NUCLEOPHILIC AROMATIC 18F-FLUORINATION
摘要
The present invention describes using fluorous chemistry in n.c.a. nucleophilic aromatic 18F-fluorination reactions by using perfluoro-aryliodonium salts as a precursor for aromatic nucleophilic substitution using a [18F] F- anion to displace a suitable leaving group from an electron deficient benzene ring. The results showed that using perfluoro-aryliodonium salts as a precursor is a suitable leaving group for n. c. a. nucleophilic aromatic 18F-fluorination in synthesis.. The PT-precursor seems to be quite stable. In an attempt to purify the crude 18F-labeled product using fluorous solid phase extraction (F-SPE), the radio labeled impurities decreased significantly. Thus, it is possible to use this PT methodology to simplify and speed up purification methods.
申请公布号
WO2009073273(A2)
申请公布日期
2009.06.11
申请号
WO2008US78547
申请日期
2008.10.02
申请人
GE HEALTHCARE LIMITED;MEDI-PHYSICS, INC.;LANGSTROM, BENGT;KARIMI, FARHAD