SYSTEM AND METHOD TO QUANTIFY CIRCADIAN ENTRAINMENT DISRUPTION

摘要

A method of quantifying circadian entrainment disruption is disclosed. At least one time series set of activity information is obtained. At least one time series set of light-dose information is obtained which corresponds to the at least one set of activity information. The at least one set of light-dose information is transformed with a logistic stimulus response function. The transformed activity information and the transformed light-dose information are circularly cross-correlated to yield an entrainment correlation function. The entrainment correlation function is spectrally analyzed. A phasor analysis of the entrainment correlation function is completed based at least in part on the spectral analysis of the entrainment correlation function. A system for quantifying circadian entrainment disruption is also disclosed.