<p>A treatment for prostate cancer using cyclin-dependent kinase inhibitors is provided. The effects of cyclin-dependent kinase inhibitors on the survival of prostate cancer cells was examined. Roscovitine, R-roscovitine, and CGP74514A were shown to induce the apoptosis of LNCaP and LNCaP-Rf cells, both of which express wild-type p53. The cyclin-dependent kinase inhibitors of the present invention induce the mitochondria-mediated apoptosis of prostate cancer cells by a dual mechanism: p53 accumulation and XIAP depletion.</p>
申请公布号
WO2006132675(A3)
申请公布日期
2009.06.11
申请号
WO2005US46112
申请日期
2005.12.20
申请人
UNIVERSITY OF SOUTH FLORIDA;MOHAPATRA, SUBHRA;PLEDGER, JACK, W.