HIGH-STRINGENCY SCREENING OF TARGET-BINDING PARTNERS USING A MICROFLUDIC DEVICE
摘要
<p>The invention provides a method of screening a library of candidate agents by contacting the library with a target in a reaction mixture under a condition of high stringency, wherein the target includes a tag that responds to a controllable force applied to the tag, and passing the members of the library through a microfluidic device in a manner that exposes the library members to the controllable force, thereby displacing members of the library that are bound to the target relative to their unbound counterparts. Kits and systems for use with the methods of the invention are also provided.</p>
申请公布号
WO2009073063(A2)
申请公布日期
2009.06.11
申请号
WO2008US11452
申请日期
2008.10.03
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;SOH, HYONGSOK;LOU, XINHUI;LAGALLY, ERIC