HOMOGENIZATION OF A RADIOPHARMACEUTICAL USING SONIFICATION AND/OR ROTOR-STATOR TECHNOLOGY TO PRODUCE A HOMOGENOUS SUSPENSION, EMULSION, MIXTURE OR SOLID SUSPENSION OF IMMISCIBLE INGREDIENTS

摘要

A homogenous dispersion of aqueous droplets of a radiopharmaceutical or radiodiagnostic agent within a non-aqueous medium and method of making the same is provided. The homogenous dispersion is largely free of impurities and constitutes a substantially uniform distribution of sodium thiosulfate and radiopharmaceutical which is stable for a time sufficient to fill and solidify within gel capsules. In making the homogenous dispersion, dry sodium thiosulfate and dry potassium phosphate dibasic anhydrous are uniformly dispersed within non-aqueous, liquid polyethylene glycol.