| 摘要 |
PROBLEM TO BE SOLVED: To provide a method of forming effectively modified minute particles and an improved inspection method of a biological substance that uses the minute particle as biological marker. SOLUTION: A surface of a substrate for fixing the minute particles in a single layer is vapor-deposited with Au in a predetermined thickness. While, particle fixing liquid is manufactured by using materials for inhibiting static repulsive force between 1-ethyl-3(3-dimethylaminopropyl)carbodiimidehydrochloride (commonly called EDC), NaCl or KCl, and the like, and applied on the substrate with the particle suspension liquid made, by mixing the particles to the particle fixing liquid on the vapor deposited substrate surface with the prescribed thickness of Au, where the minute particles are fixed in a single layer. On the surface of the single layer of the fixed minute particle, transition metal, metal or semiconductor is vapor-deposited for forming the modified particles. For peeling the modified particles from the substrate, an ultrasonic cleansing device is used, by activating the ultrasonic waves to the substrate for setting forward the peeling. For the case where the modified particles is to be modified by the biological function molecules to be used as a marker for inspecting biologocal material, the reflection electrons from the modified particles are used. COPYRIGHT: (C)2009,JPO&INPIT
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