BONE SCAFFOLDS, INJECTABLE BONE REPAIR MATERIALS AND METHODS FOR BONE REPAIR

摘要

A method of bone repair that includes applying to a subject a composite that comprises at least one calcium phosphate, at least one polyamine polymer material; and a linking structure covalently crosslinking the calcium phosphate to the polyamine polymer material, wherein the linking structure is covalently bonded to the calcium phosphate via a - O-Si- moiety or an isocyanato moiety and the linking structure is covalently bonded to the polyamine polymer material via amine groups of the polyamine polymer. Also disclosed is a combination of ingredients comprising at least one polyamine polymer; and calcium phosphate particles that are substantially coated with at least one functional group that is covalently reactive with amine groups on the polyamine polymer; wherein the ingredients are adapted for injection into a subject for forming a bone replacement material in vivo.