发明名称 |
COMPOSITIONS AND METHODS FOR EFFECTING NAD+ LEVELS USING A NICOTINAMIDE PHOSPHORIBOSYL TRANSFERASE INHIBITOR |
摘要 |
The present invention relates to methods for decreasing cellular DNA repair in a target patient; decreasing cellular NAD+ biosynthesis in a target patient; increasing efficiency of radiation therapy in a target patient; modulating nicotinamide phosphoribosyl transferase activity in a patient; or sensitizing a patient to a DNA damaging therapy. The invention relates to methods for treating a patient who received a toxic dose of an nicotinamide phosphoribosyl transferase inhibitor. The invention also relates to pharmaceutical compositions comprising a physiologically acceptable carrier; an effective amount of a NMPRT inhibitor; and nicotinic acid. The invention also relates to methods for treating a patient diagnosed with or suspected to have a cancer deficient in nicotinic acid pathway. |
申请公布号 |
WO2009072004(A2) |
申请公布日期 |
2009.06.11 |
申请号 |
WO2008IB03828 |
申请日期 |
2008.09.25 |
申请人 |
GEMIN X PHARMACEUTICALS CANADA, INC.;ROULSTON, ANNE;BEAUPARLANT, PIERRE |
发明人 |
ROULSTON, ANNE;BEAUPARLANT, PIERRE |
分类号 |
A61K31/455;A61K31/44;A61K31/4409;A61K31/4425;A61P35/00;A61P39/00 |
主分类号 |
A61K31/455 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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