发明名称 |
1-[1-(3,4-DIALKOXYBENZYL)-1H-PYRROL COMPOUNDS, PROCESS FOR PREPARING THEREOF, AND PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ARTHRITIS, ATOPIC DERMATITIS, TUMOR AND DEGENERATIVE BRAIN DISEASES COMPRISING THE SAME |
摘要 |
A 1-[1-(3,4-dialkoxybenzyl)-1H-pyrrole compound is provided to obtain excellent inhibition activity to PDE-4 enzyme and high enzyme selectivity. A 1-[1-(3,4-dialkoxybenzyl)-1H-pyrrole compound is denoted by the chemical formula 1. In the chemical formula 1, R1 and R2 are different or same. The R1 and R2 are individually hydrogen, saturated or unsaturated alkyl(C1-C7) of straight chain and branch chain, saturated or unsaturated alkyl(C1-C7) of straight chain and branch chain containing oxygen, nitrogen or sulfur, cycloalkyl of C3-C7, and cycloalkyl of C3-C7 containing oxygen, nitrogen, or sulfur. R1 and R2 is connected with (C1 - C3) alkylene or (C1 - C3) alkylene containing halogen.
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申请公布号 |
KR20090058752(A) |
申请公布日期 |
2009.06.10 |
申请号 |
KR20070125491 |
申请日期 |
2007.12.05 |
申请人 |
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY |
发明人 |
JEON, DONG JU;SONG, JONG HWAN;LEE, GE HYEONG;KIM, IK YON |
分类号 |
C07D207/325;A61K31/40;A61P29/00;A61P35/00 |
主分类号 |
C07D207/325 |
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