P38 INHIBITORS AND APPLICATION METHODS

摘要

FIELD: chemistry. ^ SUBSTANCE: invention can be applied in medicine and concerns inhibitors of MaR-kinase p38 of formula where W represents N or O, when Y represents C, and W represents C, when Y represents N; U represents CH or N; V represents C-E or N; X represents O, S, SO, SO2, NH, C=O,-C=NOR1 or CHOR1; B represents H or NH2; R1, E and A stands for H or various alkyl, heteroalkyl, aromatic and heteroaromatic substitutes. ^ EFFECT: production of new biologically active compounds. ^ 48 cl, 138 ex, 54 dwg