发明名称 |
IMPROVED METHOD OF PRODUCTION OF 9-CIS-RETINOIC ACID |
摘要 |
Improved method of production of 9-(Z)-retinoic acid, in which a) a beta-formyl-crotonic acid C1-C10 alkyl or phenyl ester is reacted with an isolated 9-(Z)-C15-triarylphosphonium salt by the Wittig reaction in the presence of a base to the corresponding 9-(Z)-retinoic acid ester; which b) is then saponified with a base to the corresponding 9-(Z)-retinoic acid carboxylate and then, following protonation with an acid, the desired 9-(Z)-retinoic acid is obtained, and improved method for the enrichment and isolation of the 9-(Z)-C15-triarylphosphonium salt. |
申请公布号 |
EP2066624(A1) |
申请公布日期 |
2009.06.10 |
申请号 |
EP20070818482 |
申请日期 |
2007.09.27 |
申请人 |
DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG |
发明人 |
STANEK, MICHAEL;ESSL, STEFAN;KNOPP, MONIKA;KUEBEL, ERWIN |
分类号 |
C07C403/20;C07F9/54 |
主分类号 |
C07C403/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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