A process for the preparation of (S)(+)-3-(aminomethyl)-5-methylhexanoic acid

摘要

A process for the preparation of a compound of formula (I),
comprising:
a) the reaction of a compound of formula (II)
with hydrazine to obtain a compound of formula (III),
b) the conversion of a compound of formula (III) by rearrangement via formation of nitrene/isocyanate, in a solvent of formula R 1 -OH, wherein R 1 is as herein defined, to obtain a compound of formula (IV);
c) the enantiomeric enrichment of a compound of formula (IV) to obtain the enantiomer (S) of a compound of formula (V)
d) the hydrolysis of a compound of formula (V).