发明名称 |
Tiotropium salts, method for their production and medicinal formulas containing them |
摘要 |
<p>Preparation of new tiotropilium salts (1) by subjecting a different tiotropilium salt (2) to anion exchange with an ion source in a solvent. Preparation of new tiotropilium salts of formula (1) by subjecting a different tiotropilium salt of formula (2) to anion exchange with an ion source (Kat-X) in a solvent. [Image] X : anion; Y : anion, different from X, i.e. halo, 1-10C alkyl-sulfonate or -sulfate, or 6-10C arylsulfonate; Kat : cation. An independent claim is also included for new compounds (1) and (2), except where Y/X = bromo, optionally as solvates or hydrates. ACTIVITY : Antiasthmatic. No details of tests for antiasthmatic activity are given. MECHANISM OF ACTION : Anticholinergic.</p> |
申请公布号 |
EP2067779(A1) |
申请公布日期 |
2009.06.10 |
申请号 |
EP20090153379 |
申请日期 |
2004.10.29 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH;BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG |
发明人 |
BANHOLZER, ROLF;SIEGER, PETER;PFRENGLE, WALDEMAR |
分类号 |
C07D451/10;A61K31/46;A61K31/4745;A61P11/00;C07D451/06;C07D491/08 |
主分类号 |
C07D451/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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