发明名称 Purine derivatives
摘要 The present invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is methyl, ethyl or isopropyl, and the other is H; R3 and R4 are each independently H, branched or un branched C1-C6 alkyl, or aryl, and wherein at least one of R3 and R4 is other than H; R5 is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups; R6, R7, R8 and R9 are each independently H, halogen, NO2, OH, OMe, CN, NH2, COOH, CONH2, or SO2NH2. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, CNS disorders, diabetes, stroke, alopecia or neurodegenerative disorders.
申请公布号 US7544689(B2) 申请公布日期 2009.06.09
申请号 US20050238533 申请日期 2005.09.28
申请人 CYCLACEL LIMITED;CANCER RESEARCH TECHNOLOGY LIMITED 发明人 FISCHER PETER MARTIN;JARMAN MICHAEL;MCDONALD EDWARD;NUTLEY BERNARD;RAYNAUD FLORENCE;WILSON STUART;WORKMAN PAUL
分类号 C07D473/16;A61K31/52;A61P3/10;A61P9/00;A61P17/06;A61P17/14;A61P25/28;A61P31/12;A61P31/14;A61P31/20;A61P35/00;A61P35/02 主分类号 C07D473/16
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