STEREOCOMPLEXED POLY(ETHYLENE OXIDE)-POLY(PROPYLENE OXIDE)-POLY (ETHYLENE OXIDE) MULTI-BLOCK COPOLYMERS, HYDROGEL FOR SUSTAINED DELIVERY OF MACROMOLECULAR DRUGS USING THE SAME, AND METHOD OF FABRICATING THEREOF

摘要

A stereocomplexed poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) multi-block copolymer is provided to ensure biodegradation property and temperature sensitivity, and to show a sol-gel phase transition phenomenon in specific concentration. A stereocomplexed poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) multi-block copolymer comprises the steps of: polymerizing D-lactic acid or L-lactic acid low polymers which are mutual isomers, to both ends of a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer represented by chemical formula (I) to prepare a polymer represented by chemical formula (II); and polymerizing the polymer represented by chemical formula (II) to prepare a represented by chemical formula (III). In chemical formulae, x is 10~1,000; y is 10~1,700; n is 2~100; and m is an integer of 2~10.