发明名称 |
ENHANCED GENERATION OF CYTOTOXIC T-LYMPHOCYTES BY IL-21 MEDIATED FOXP3 SUPPRESSION |
摘要 |
A method of carrying out adoptive immunotherapy by administering a subject an antigen-specific cytotoxic T lymphocytes (CTL) preparation in a treatment-effective amount is described. In the method, the CTL preparation is preferably administered as a preparation of an in vitro antigen-stimulated and expanded primate CTL population, the CTL population: (i) depleted of FoxP3+ T lymphocytes prior to antigen stimulation; (ii) antigen-stimulated in vitro in the presence of interleukin-21; or (iii) both depleted of FoxP3+ T lymphocytes prior to antigen stimulation and then antigen-stimulated in vitro in the presence of interleukin-21. Methods of preparing such compositions, and compositions useful for carrying out the adoptive immunotherapy, are also described. |
申请公布号 |
WO2009045308(A3) |
申请公布日期 |
2009.06.04 |
申请号 |
WO2008US11088 |
申请日期 |
2008.09.25 |
申请人 |
FRED HUTCHINSON CANCER RESEARCH CENTER;YEE, CASSIAN;LI, YONGQING |
发明人 |
YEE, CASSIAN;LI, YONGQING |
分类号 |
A61K48/00;A61K31/41;A61K39/00;C12N5/22 |
主分类号 |
A61K48/00 |
代理机构 |
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