发明名称 |
AFFINITY STRUCTURES FOR THE SPECIFIC BINDING OF SUBSTANCES BY MEANS OF NON-COVALENT INTERACTION SHAPES |
摘要 |
The present invention relates to a method for the production of affinity binding agents having affine or highly affine binding structures for non-covalent interaction shapes, comprising the following steps: a) contacting a target substance having at least one ligand capable of a non-covalent bond to the target substance for a period of time that is sufficient for the at least one ligand to accumulate at the target regions of the target substance and form a ligand-target substance complex; b) embedding the complex into a component providing a structure and fixing the same via a bond of the ligand(s) of the complex to the component providing a structure; c) removing the target substance such that a structure results that has a defined spatial arrangement of the ligand(s), which has the capacity to rebind the respective target substance in a specific manner. The invention further relates to affinity binding agents having affine or highly affine binding structures for non-covalent interaction shapes obtained using the above method and comprising a component providing a structure and at least one ligand integrated into the component providing a structure, wherein the component providing a structure holds the at least one ligand in a certain spatial arrangement that enables the specific binding of the ligand(s) to the target substance. |
申请公布号 |
WO2009068244(A1) |
申请公布日期 |
2009.06.04 |
申请号 |
WO2008EP09984 |
申请日期 |
2008.11.25 |
申请人 |
FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;ANDRESEN, HEIKO;BIER, FRANK;KATTERLE, MARTIN |
发明人 |
ANDRESEN, HEIKO;BIER, FRANK;KATTERLE, MARTIN |
分类号 |
G01N33/53;C08G63/91;G01N33/531 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|