发明名称 |
MODIFIED T CELL RECEPTORS AND RELATED MATERIALS AND METHODS |
摘要 |
The invention is directed to a modified T cell receptor (TCR) comprising an amino acid sequence of a wild-type (WT) TCR with one or more amino acid substitutions in the CDR2 and/or CDR3 regions of the alpha and/or beta chains of the TCR, wherein the modified TCR, as compared to the WT TCR, (i) has an enhanced ability to recognize target cells when expressed by CD4+ T cells and/or CD8+ T cells and (ii) does not exhibit a decrease in antigen specificity when expressed by the CD4+ T cells and/or CD8+ T cells. Polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, and pharmaceutical compositions related to the modified TCR also are part of the invention. Further, the invention is directed to methods of treating or preventing a disease in a host and methods of detecting a diseased cell in a host. |
申请公布号 |
WO2009042570(A3) |
申请公布日期 |
2009.06.04 |
申请号 |
WO2008US77333 |
申请日期 |
2008.09.23 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;ROBBINS, PAUL F.;ROSENBERG, STEVEN A.;MORGAN, RICHARD A. |
发明人 |
ROBBINS, PAUL F.;ROSENBERG, STEVEN A.;MORGAN, RICHARD A. |
分类号 |
C07K14/735 |
主分类号 |
C07K14/735 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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